β斑塊, 近紅外熒光成像, 分子探針, 評述,分析化學">
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引用本文:   李鈺瑩, 崔孟超. 腦內β-淀粉樣蛋白斑塊近紅外熒光探針的研究進展. 分析化學, 2019, 47(10): 1524-1536. doi:  10.19756/j.issn.0253-3820.191489 [復制]

Citation:   LI Yu-Ying , CUI Meng-Chao . Progress of Near-Infrared Fluorescent Probes for β-Amyloid Plaques in the Brain. Chinese Journal of Analytical Chemistry, 2019, 47(10): 1524-1536. doi: 10.19756/j.issn.0253-3820.191489 [復制]

腦內β-淀粉樣蛋白斑塊近紅外熒光探針的研究進展

通訊作者:  崔孟超, [email protected]

收稿日期: 2019-08-10

基金項目: 本文系國家自然科學基金項目(No.21571022)資助

Progress of Near-Infrared Fluorescent Probes for β-Amyloid Plaques in the Brain

Corresponding author:  CUI Meng-Chao , [email protected]

Received Date:  2019-08-10

Fund Project:  This work was supported by the National Natural Science Foundation of China (No. 21571022)

β-淀粉樣蛋白(β-Amyloid,Aβ)作為阿爾茨海默病(Alzheimer's disease,AD)的一個重要病理學特征,被認為是實現AD早期診斷的重要靶點。近年來,熒光成像技術,尤其是近紅外熒光成像技術(Near-infrared imaging)得到了快速發展。由于其靈敏度高,操作簡便,能夠避免生物組織自發熒光干擾,已成為體外生物樣本分析和小動物活體成像的重要手段。因此,靶向于腦內Aβ斑塊的近紅外熒光探針,對于AD的臨床前研究、組織病理學檢查、治療藥物的篩選和小動物模型的構建具有重要的意義。本文主要對基于分子內電荷轉移(Intramolecular charge transfer,ICT)機理的近紅外Aβ熒光探針進行歸納和總結,分析分子結構對于探針光學性質和生物學性質的影響,為開發新型高靈敏度的近紅外Aβ熒光探針提供了思路。

關鍵詞:   阿爾茨海默病, Aβ斑塊, 近紅外熒光成像, 分子探針, 評述
Key words:   Alzheimer's disease, β-Amyloid plaques, Near-infrared fluorescence imaging, Probes, Review
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目錄

腦內β-淀粉樣蛋白斑塊近紅外熒光探針的研究進展

李鈺瑩, 崔孟超

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