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引用本文:   齊擦毛吉, 沙正悅, 李鮮嬋. 單一神經囊泡的電分析化學研究. 分析化學, 2019, 47(10): 1502-1511. doi:  10.19756/j.issn.0253-3820.191443 [復制]

Citation:   QI Camaoji , SHA Zheng-Yue , LI Xian-Chan . Electrochemical Analysis of Single Neuronal Vesicles. Chinese Journal of Analytical Chemistry, 2019, 47(10): 1502-1511. doi: 10.19756/j.issn.0253-3820.191443 [復制]

單一神經囊泡的電分析化學研究

通訊作者:  李鮮嬋, [email protected]

收稿日期: 2019-07-25

基金項目: 本文系中央高校師資隊伍建設項目(No.103010190040100)和中央民族大學青年拔尖學術團隊建設項目(No.2019QNBJ02)資助

Electrochemical Analysis of Single Neuronal Vesicles

Corresponding author:  LI Xian-Chan , [email protected]

Received Date:  2019-07-25

Fund Project:  This work was supported by the Construction Fee for Teachers in Central Colleges and Universities of China (No.103010190040100) and the Youth Excellent Academic Team Construction Project of Minzu University of China (No. 2019QNBJ02).

近年來,神經活動過程中化學遞質的儲存、釋放和作用規律成為研究熱點。神經囊泡作為執行化學遞質儲存和釋放的主要亞細胞器,一直備受關注。與常見的囊泡分析技術相比,電分析化學方法由于具有較高的時間分辨率和靈敏度,特別是微納米電極的使用,使電分析化學在單一神經囊泡的分析方面顯示出獨特的優勢。近年來,單囊泡電化學計數法和阻抗脈沖法在單囊泡分析方面的研究進展迅速。單囊泡電化學計數法基于電場作用下囊泡膜在電極表面破裂,可實現單一囊泡內儲存神經遞質的定量分析。阻抗脈沖法可通過測定囊泡通過微納米孔時引起的離子電流信號的變化,研究囊泡的尺寸、表面電荷、濃度及柔韌性等參數或特性。本文以單一神經囊泡分析為切入點,介紹了近年來單囊泡電化學計數法與阻抗脈沖法在單一囊泡分析領域的重要進展,展望了這兩種方法在神經化學和生物醫學等領域的應用前景。

關鍵詞:   腦科學, 神經囊泡, 電分析化學, 單囊泡原位電化學計數法, 阻抗脈沖法, 評述
Key words:   Brain science, Nerve vesicles, Electroanalytical chemistry, Vesicle impact electrochemical cytometry, Resistive-pulse method, Review
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目錄

單一神經囊泡的電分析化學研究

齊擦毛吉, 沙正悅, 李鮮嬋

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