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引用本文:   魏春蓉, 裴為華. 植入式多通道神經微電極的發展. 分析化學, 2019, 47(10): 1455-1465. doi:  10.19756/j.issn.0253-3820.191430 [復制]

Citation:   WEI Chun-Rong , PEI Wei-Hua . Development of Implantable Multichannel Nural Mcroelectrodes. Chinese Journal of Analytical Chemistry, 2019, 47(10): 1455-1465. doi: 10.19756/j.issn.0253-3820.191430 [復制]

植入式多通道神經微電極的發展

通訊作者:  裴為華, [email protected]

收稿日期: 2019-07-22

基金項目: 本文系國家重點技術研發計劃項目(Nos.2017YFA0205903,2017YFA0701100,2016YFB0402405)、國家自然科學基金項目(Nos.61634006,61671424)、上海市科委基礎研究項目(No.16JC1400101)、中國科學院戰略性先導科技專項(Nos.XDB32030100、XDB32040200)和中國科學院重點項目(No.QYZDY-SSW-JSC004)資助

Development of Implantable Multichannel Nural Mcroelectrodes

Corresponding author:  PEI Wei-Hua , [email protected]

Received Date:  2019-07-22

Fund Project:  This work was supported by the National Key Technologies Research and Development Program (Nos. 2017YFA0205903, 2017YFA0701100, 2016YFB0402405), the National Natural Science Foundation of China (Nos. 61634006, 61671424), the Basic Research Project of Shanghai Science and Technology Commission (No. 16JC1400101), the Strategic Priority Research Program of Chinese Academy of Sciences Pilot Project (Nos. XDB32030100, XDB32040200), and the Key Programs of Chinese Academy of Sciences (No. QYZDY-SSW-JSC004).

人類的大腦約由800億神經細胞構成,這些神經元之間的連接將大腦組成了一個超復雜的神經網絡,要研究大腦的功能機制,破譯其神經網絡的信息編碼原理,一個重要的方法是在大腦神經元網絡中,同時觀察、記錄盡可能多的單個神經元活動信號。植入式多通道神經微電極作為一種可實時記錄多個神經元峰電位信號的器件,在神經信號的時間分辨率和設備的便捷性方面有著其它神經成像技術不可替代的優點。在不影響大腦功能甚至動物行為的前提下,為了在大腦中植入通道數更多的電極,需要在植入式多通道電極的材料、結構、集成方式和植入及封裝方法等方面不斷地進行改進創新和優化。本文簡要回顧了多通道微電極技術的發展歷史,重點介紹了采用微加工技術制備植入式多通道微電極的發展歷程和研究現狀,對未來的發展趨勢進行了展望。

關鍵詞:   植入式神經微電極, 微加工技術, 微通道電極, 薄膜電極, 電極陣列, 評述
Key words:   Implantable neural microelectrodes, Micromachining technology, Multichannel microelectrodes, thin film electrode, Electrode array, Review
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目錄

植入式多通道神經微電極的發展

魏春蓉, 裴為華

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