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引用本文:   韓增鵬, 施祥瑋, 應敏, 鄭寧, 李梅, 張志建, 吳陽, 王華東, 王杰, 胡亮, 賈凡, 徐富強. 神經環路示蹤工具病毒的研究進展. 分析化學, 2019, 47(10): 1639-1650. doi:  10.19756/j.issn.0253-3820.191428 [復制]

Citation:   HAN Zeng-Peng , SHI Xiang-Wei , YING Min , ZHENG Ning , LI Mei , ZHANG Zhi-Jian , WU Yang , WANG Hua-Dong , WANG Jie , HU Liang , JIA Fan , XU Fu-Qiang . Tools for Neural Circuit Tracing Based on Neurotropic Viruses. Chinese Journal of Analytical Chemistry, 2019, 47(10): 1639-1650. doi: 10.19756/j.issn.0253-3820.191428 [復制]

神經環路示蹤工具病毒的研究進展

通訊作者:  徐富強, [email protected]

收稿日期: 2019-07-20

基金項目: 本文系國家自然科學基金項目(Nos.91632303,31830035,31771197,31771156)、中國科學院戰略性先導科技專項(B類)(No.XDBS01030200)和國家重點基礎研究發展計劃(973計劃)項目(No.2015CB755600)資助

Tools for Neural Circuit Tracing Based on Neurotropic Viruses

Corresponding author:  XU Fu-Qiang , [email protected]

Received Date:  2019-07-20

Fund Project:  This work was supported by the National Natural Science Foundation of China (Nos. 91632303, 31830035, 31771197, 31771156), the Strategic Priority Research Program (B) (No. XDBS01030200), and the National Basic Research Program of China (No. 2015CB755600).

腦是機體最為復雜的系統,決定著情感、記憶、學習等生理活動。神經環路是腦行使功能的基礎,明確神經環路的構成和工作原理,對于認識腦、利用腦和保護腦具有十分重要的意義。神經環路結構和功能解析涉及環路標記、成像和數據分析等。本文以環路標記為出發點,重點介紹了以嗜神經病毒為基礎的神經環路示蹤工具體系及其應用技術,闡述了常用的嗜神經工具病毒類別及其特性、遺傳改造、選用原則及應用限制等問題,并對不跨突觸示蹤工具系統、跨單級突觸示蹤工具系統和跨多級突觸示蹤工具系統進行介紹,以期幫助讀者了解當前腦科學研究中不可替代的環路標記新方法及其研究新進展。

關鍵詞:   神經環路, 示蹤工具病毒, 逆向跨突觸, 順向跨突觸, 輔助工具病毒, 評述
Key words:   Neural circuit, Tools based on neurotropic virus, Retrograde, Anterograde, Helper virus, Review
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目錄

神經環路示蹤工具病毒的研究進展

韓增鵬, 施祥瑋, 應敏, 鄭寧, 李梅, 張志建, 吳陽, 王華東, 王杰, 胡亮, 賈凡, 徐富強

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