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引用本文:   都展宏, 魯藝, 王立平. 神經疾病診斷與研究中的神經遞質檢測技術. 分析化學, 2019, 47(10): 1651-1663. doi:  10.19756/j.issn.0253-3820.191427 [復制]

Citation:   DU Zhan-Hong , LU Yi , WANG Li-Ping . Neurotransmitter Sensing in Diagnosis and Research of Neurological Diseases. Chinese Journal of Analytical Chemistry, 2019, 47(10): 1651-1663. doi: 10.19756/j.issn.0253-3820.191427 [復制]

神經疾病診斷與研究中的神經遞質檢測技術

通訊作者:  都展宏, [email protected]

收稿日期: 2019-07-20

基金項目: 本文系國家自然科學基金項目(No.31700936)、廣東省重點領域研發計劃項目(No.2018B030331001)和深圳市基礎研究計劃項目(No.JCYJ20160531174444711)資助

Neurotransmitter Sensing in Diagnosis and Research of Neurological Diseases

Corresponding author:  DU Zhan-Hong , [email protected]

Received Date:  2019-07-20

Fund Project:  This work was supported by the National Natural Science Foundation of China (No.31700936), the Science and Technology Planning Project of Guangdong Province (No.2018B030331001), and the Shenzhen Governmental Basic Research Project (No. JCYJ20160531174444711).

神經遞質的在體檢測不僅可能作為帕金森氏癥、阿爾茲海默癥、抑郁癥等多種神經疾病的生物標記物,同時,這類傳感器也可作為研究獎賞、成癮、厭惡等多種行為產生機制的重要工具。近年來,多種檢測神經遞質的分析技術已得到了長足的發展,但目前應用于疾病研究和在體檢測的傳感技術與材料尚面臨一些困難,只有較少的應用實例。本文主要介紹了癲癇、帕金森氏癥、腦卒中、阿爾茲海默癥、精神分裂等疾病中神經遞質發揮的重要作用及其檢測的科學意義,探討了在體傳感器技術的進展,以及可能用于解析疾病神經環路機制的相關技術和器件,重點探討了多種納米材料、導電聚合物材料和生物分子作為在體傳感器組成成分的應用技術,以及未來這些新技術、新材料面臨的機遇與挑戰。

關鍵詞:   神經遞質, 生物傳感器, 納米材料, 成像技術, 疾病診斷, 評述
Key words:   Neurotransmitters, Biosensors, Nanomaterials, Imaging, Disease diagnosis, Review
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目錄

神經疾病診斷與研究中的神經遞質檢測技術

都展宏, 魯藝, 王立平

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