首頁 雜志概況 投稿須知 在線投稿 在線閱讀 征訂啟事 廣告服務 行業資訊 企業動態 資料中心  專訪報道 會展信息 ENGLISH

引用本文:   王晉芬, 田慧慧, 方英. 植入式柔性神經電極在活體腦電信號檢測中的研究進展. 分析化學, 2019, 47(10): 1549-1558. doi:  10.19756/j.issn.0253-3820.191411 [復制]

Citation:   WANG Jin-Fen , TIAN Hui-Hui , FANG Ying . Implantable and Flexible Electronics for in Vivo Brain Activity Recordings. Chinese Journal of Analytical Chemistry, 2019, 47(10): 1549-1558. doi: 10.19756/j.issn.0253-3820.191411 [復制]

植入式柔性神經電極在活體腦電信號檢測中的研究進展

通訊作者:  王晉芬, [email protected]

收稿日期: 2019-07-18

基金項目: 本文系國家自然科學基金項目(Nos.21790393,61971150)和中國科學院先導B項目(No.XDB32030100)資助

Implantable and Flexible Electronics for in Vivo Brain Activity Recordings

Corresponding author:  WANG Jin-Fen , [email protected]

Received Date:  2019-07-18

Fund Project:  This work was supported by the National Natural Science Foundation of China (Nos.21790393, 61971150) and the Strategic Priority Research Program of Chinese Academy of Sciences (No.XDB32030100).

植入式神經電極是記錄神經電生理信號的一種重要工具,具有單細胞的空間分辨率和亞毫秒級的時間分辨率,在神經科學和神經修復領域具有重要的應用。微納米加工技術的發展,為植入式神經電極的構建提供了更多的解決方案。基于微納米加工的植入式剛性電極,由于存在與大腦組織的力學性能不匹配的問題,容易造成大腦組織的免疫反應,影響神經電信號的長期穩定測量。而近年出現的新型植入式柔性神經電極,可與腦組織形成兼容性的界面,引起的免疫反應小,有利于神經電信號的長期穩定測量。此外,植入式柔性神經電極的微型化、高密度和多功能集成也是腦研究新技術的研究熱點。本文主要對近年用于活體腦電信號檢測的植入式柔性神經電極的相關研究進展進行了評述,包括柔性神經電極結構、電極組織界面、植入方法、微型化方法和集成方法等。

關鍵詞:   柔性神經電極, 植入式神經電極, 免疫反應, 電生理記錄, 活體, 評述
Key words:   Flexible electronics, Implantable electronics, Immune reactivity, Electrophysiological recording, In vivo, Review
[1]

Chen R, Canales A, Anikeeva P. Nat. Rev. Mater., 2017, 2(2):16093

[2]

Jun J J, Steinmetz N A, Siegle J H, Denman D J, Bauza M, Barbarits B, Lee A K, Anastassiou C A, Andrei A, Aydln C, Barbic M, Blanche T J, Bonin V, Couto J, Dutta B, Gratiy S L, Gutnisky D A, Häusser M, Karsh B, Ledochowitsch P, Lopez C M, Mitelut C, Musa S, Okun M, Pachitariu M, Putzeys J, Rich P D, Rossant C, Sun W L, Svoboda K, Carandini M, Harris K D, Koch C, O'Keefe J, Harris T D. Nature, 2017, 551(7679):232-236

[3]

Campbell P K, Jones K E, Huber R J, Horch K W, Normann R A. IEEE Trans. Biomed. Eng., 1991, 38(8):758-768

[4]

Cody P A, Eles J R, Lagenaur C F, Kozai T D Y, Cui X T. Biomaterials, 2018, 161:117-128

[5]

Rousche P J, Normann R A. J. Neurosci. Methods, 1998, 82(1):1-15

[6]

Lee H, Bellamkonda R V, Sun W, Levenston M E. J. Neural. Eng., 2005, 2(4):81-89

[7]

Polikov V S, Tresco P A, Reichert W M. J. Neurosci. Methods, 2005, 148(1):1-18

[8]

Salatino J W, Ludwig K A, Kozai T D Y, Purcell E K. Nat. Biomed. Eng., 2017, 1(11):862-877

[9]

Rutledge L T, Duncan J A. Nature, 1966, 210(5037):737-739

[10]

Wise K D, Angell J B, Starr A. IEEE Trans. Biomed. Eng., 1970, 17(3):238-247

[11]

Jones K E, Campbell P K, Normann R A. Ann. Biomed. Eng., 1992, 20(4):423-437

[12]

Jeong J W, Shin G, Park S Ⅱ, Yu K J, Xu L, Rogers J A. Neuron, 2015, 86 (1):175-186

[13]

Liu J, Fu T M, Cheng Z, Hong G, Zhou T, Jin L, Duvvuri M, Jiang Z, Kruskal P, Xie C, Suo Z, Fang Y, Lieber C M. Nat. Nanotechnol,. 2015, 10(7):629-636

[14]

Tybrandt K, Khodagholy D, Dielacher B, Stauffer F, Renz A F, Buzsáki G, Vörös J. Adv. Mater., 2018, 30(15):1706520

[15]

Khodagholy D, Gelinas J N, Thesen T, Doyle W, Devinsky O, Malliaras G G, Buzsáki G. Nat. Neurosci., 2015, 18(2):310-315.

[16]

Luan L, Wei X, Zhao Z, Siegel J J, Potnis O, Tuppen C A, Lin S, Kazmi S, Fowler R A, Holloway S, Dunn A K, Chitwood R A, Xie C. Sci. Adv., 2017, 3(2):e1601966

[17]

Kozai T D Y, Kipke D R. J. Neurosci. Methods, 2009, 184(2):199-205

[18]

Pas J, Rutz A L, Quilichini P P, Slézia A, Ghestem A, Kaszas A, Donahue M J, Curto V F, O'Connor R P, Bernard C, Williamson A, Malliaras G G. J. Neural. Eng., 2018, 15(6):065001

[19]

Guan S, Wang J, Gu X, Zhao Y, Hou R, Fan H, Zou L, Gao L, Du M, Li C, Fang Y. Sci. Adv., 2019, 5(3):eaav2842

[20]

Rios G, Lubenov E V, Chi D, Roukes M L, Siapas A G. Nano Lett., 2016, 16(11):6857-6862

[21]

Park S, Guo Y, Jia X, Choe H K, Grena B, Kang J, Park J, Lu C, Canales A, Chen R, Yim Y S, Choi G B, Fink Y, Anikeeva P. Nat. Neurosci., 2017, 20(4):612-619

[22]

Kim T I, Mc Call J G, Jung Y H, Huang X, Siuda E R, Li Y, Song J, Song Y M, Pao H A, Kim R H, Lu C, Lee S D, Song I S, Shin G, Al-Hasani R, Kim S, Tan M P, Huang Y, Omenetto F G, Rogers J A, Bruchas M R. Science, 2013, 340(6129):211-216

[23]

Lai H Y, Liao L D, Lin C T, Hsu J H, He X, Chen Y Y, Chang J Y, Chen H F, Tsang S, Shih Y Y. J. Neural Eng., 2012, 9(3), 036001

[24]

Kim J H, Lee G H, Kim S, Chung H W, Lee J H, Lee S M, Kang C Y, Lee S H. Biosens. Bioelectron., 2018, 117:436-443

[25]

Lecomte A, Castagnola V, Descamps E, Dahan L, Blatché M C, Dinis T M, Leclerc E, Egles C, Bergaud C. J. Micromech. Microeng., 2015, 25(12):125003

[26]

Khodagholy D, Gelinas J N, Zhao Z, Yeh M, Long M, Greenlee J D, Doyle W, Devinsky O, Buzsáki G. Sci. Adv., 2016, 2(11):e1601027

[27]

Fu T M, Hong G, Zhou T, Schuhmann T G, Viveros R D, Lieber C M. Nat. Methods, 2016, 13(10):875-882

[28]

Fu T M, Hong G, Viveros R D, Zhou T, Lieber C M. Proc. Natl. Acad. Sci. USA, 2017, 114(47):E10046-E10055

[29]

Hong G, Yang X, Zhou T, Lieber C M. Curr. Opin. Neurobiol., 2018, 50:33-41

[30]

Zhou T, Hong G, Fu T M, Yang X, Schuhmann T G, Viveros R D, Lieber C M. Proc. Natl. Acad. Sci. USA, 2017, 114(23):5894-5899

[31]

Yang X, Zhou T, Zwang T J, Hong G, Zhao Y, Viveros R D, Fu T M, Gao T, Lieber C M. Nat. Mater., 2019, 18(5):510-517

[32]

Callaway E M, Garg A K. Nature, 2017, 551(7679):172-173

[33]

Canales A, Jia X, Froriep U P, Koppes R A, Tringides C M, Selvidge J, Lu C, Hou C, Wei L, Fink Y, Anikeeva P. Nat. Biotechnol., 2015, 33(3):277-284

計量
  • PDF下載量(29)
  • 文章訪問量(245)
  • HTML全文瀏覽量(2)

目錄

植入式柔性神經電極在活體腦電信號檢測中的研究進展

王晉芬, 田慧慧, 方英

Figures and Tables

3d全部独胆三地村胆码