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引用本文:   王昕, 李平, 張雯, 唐波. 小鼠活體腦部生物活性分子的熒光成像研究進展. 分析化學, 2019, 47(10): 1537-1548. doi:  10.19756/j.issn.0253-3820.191408 [復制]

Citation:   WANG Xin , LI Ping , ZHANG Wen , TANG Bo . Recent Advances in Fluorescence Imaging of Bioactive Molecules in Neurons and in Vivo. Chinese Journal of Analytical Chemistry, 2019, 47(10): 1537-1548. doi: 10.19756/j.issn.0253-3820.191408 [復制]

小鼠活體腦部生物活性分子的熒光成像研究進展

通訊作者:  李平, [email protected]; 唐波, [email protected]

收稿日期: 2019-07-19

基金項目: 本文系國家自然科學基金項目(Nos.21535004,91753111,21675105)、山東省自然科學基金重大基礎研究項目(No.2018YFJH0502)和國家科技重大專項(重大新藥創制)(No.2017ZX09301030004)資助

Recent Advances in Fluorescence Imaging of Bioactive Molecules in Neurons and in Vivo

Corresponding author:  LI Ping , [email protected]; TANG Bo , [email protected]

Received Date:  2019-07-19

Fund Project:  This work was supported by the National Natural Science Foundation of China (Nos. 21535004, 91753111, 21675105), the Key Research and Development Program of Shandong Province, China (No. 2018YFJH0502) and the National Major Scientific and Technological Special Project for "Significant New Drugs Development" (No. 2017ZX09301030004).

大腦在分子水平上具有獨特的化學組成和反應活性。腦部的生物活性分子(包括金屬離子,活性氧物種,神經遞質及神經遞質水解酶等)在腦功能的行使過程中,扮演著不同卻又極其關鍵的角色。正常穩態濃度的生物活性分子對維持穩定的腦部和功能發揮了重要作用,而生物活性分子水平的異常變化又與帕金森病、阿爾茲海默癥、抑郁癥等多種腦部疾病的發生與發展密切相關。因此探究大腦中生物活性分子的濃度及調控作用,對揭示大腦的奧秘、理解腦部疾病的發生和發展具有重要作用。熒光成像方法具有高靈敏、高時空分辨、易操作等優勢,是探究大腦中生物活性分子的真實濃度和功能的重要工具。近年來,隨著熒光成像技術的發展,研究者構建了多種熒光探針用于檢測鼠腦中生物活性分子。本文綜述了近年來用于大腦中生物活性分子檢測的分子探針、納米探針及蛋白探針的發展概況,探討了構建新型熒光探針、利用熒光成像方法進一步深入剖析生物活性分子調控大腦功能等方面的研究,對未來的發展進行了展望。

關鍵詞:   熒光探針, 腦部成像, 生物活性分子, 評述
Key words:   Fluorescent probe, Brain imaging, Bioactive molecule, Review
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目錄

小鼠活體腦部生物活性分子的熒光成像研究進展

王昕, 李平, 張雯, 唐波

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