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引用本文:   黃嫣嫣, 趙睿. 基于血腦屏障靶向多肽的腦神經分析化學研究進展. 分析化學, 2019, 47(10): 1629-1638. doi:  10.19756/j.issn.0253-3820.191358 [復制]

Citation:   HUANG Yan-Yan , ZHAO Rui . Targeted Analysis of Central Nervous System Using Blood-Brain Barrier Shuttle Peptides. Chinese Journal of Analytical Chemistry, 2019, 47(10): 1629-1638. doi: 10.19756/j.issn.0253-3820.191358 [復制]

基于血腦屏障靶向多肽的腦神經分析化學研究進展

通訊作者:  趙睿, [email protected]

收稿日期: 2019-06-26

基金項目: 本文系國家自然科學基金(Nos.21874141,91853103,21675161,21705154)和中國科學院青年創新促進會項目(No.2015027)資助

Targeted Analysis of Central Nervous System Using Blood-Brain Barrier Shuttle Peptides

Corresponding author:  ZHAO Rui , [email protected]

Received Date:  2019-06-26

Fund Project:  This work was supported by the National Natural Science Foundation of China (Nos. 21874141, 91853103, 21675161, 21705154) and the Youth Innovation Promotion Association Chinese Academy of Sciences (No. 2015027).

將用于分析檢測的分子或材料透過血腦屏障(Blood-brain barrier,BBB),使其高效靶向中樞神經系統,是實現原位、在體腦神經化學分析亟需解決的問題。多肽作為內源性生理活性物質,具有模塊化的結構,不僅設計性強、構象可預測,而且利用固相合成方法可高效、低干擾地獲得目標序列。以小分子多肽為穿梭工具,可將熒光分子、造影劑、納米顆粒等高效、快速地轉運到目標位置,為腦科學研究及相關疾病的檢測、分子機制研究提供新方法和新技術。本文圍繞BBB和多肽的特點,從BBB穿透途徑和靶向多肽設計篩選方法出發,對近年來基于多肽(Peptide shuttles)的BBB靶向分析的研究進展進行了總結和評述,期望從分子、細胞到活體的角度為腦神經分析化學研究提供參考和借鑒。

關鍵詞:   血腦屏障, 多肽, 靶向分析, 親和篩選, 評述
Key words:   Blood-brain barrier, Peptide, Targeted analysis, Affinity screening, Review
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目錄

基于血腦屏障靶向多肽的腦神經分析化學研究進展

黃嫣嫣, 趙睿

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